Focus 1: Fever and hypothermia in systemic inflammation: physiological mechanisms and mediators

Representative publications

Steiner AA, Hunter JC, Phipps SM, Nucci TB, Oliveira DL, Roberts JL, Scheck AC, Simmons DL, Romanovsky AA. Cyclooxygenase-1 or -2 — which one mediates lipopolysaccharide-induced hypothermia? Am J Physiol 297: R485-R494, 2009.

Steiner AA, Romanovsky AA. Leptin: At the crossroads of energy balance and systemic inflammation. Prog Lipid Res 46: 89-107, 2007.

Steiner AA, Chakravarty S, Rudaya AY, Herkenham M, Romanovsky AA. Bacterial lipopolysaccharide fever is initiated via Toll-like receptor 4 on hematopoietic cells. Blood 107: 4000-4002, 2006.

Steiner AA, Ivanov AI, Serrats J, Hosokawa H, Phayre AN, Robbins JR, Roberts JL, Kobayashi S, Matsumura K, Sawchenko PE, Romanovsky AA. Cellular and molecular bases of the initiation of fever. PLoS Biol 4: e284, 2006.

Ivanov AI, Steiner AA, Scheck AC, Romanovsky AA. Expression of Eph receptors and their ligands, ephrins, during lipopolysaccharide fever in rats. Physiol Genomics 21: 152-160, 2005.

Steiner AA, Dogan MD, Ivanov AI, Patel S, Rudaya AY, Jennings DH, Orchinik M, Pace TWW, O'Connor KA, Watkins LR, Romanovsky AA. A new function of the leptin receptor: mediation of the recovery from lipopolysaccharide-induced hypothermia. FASEB J 18: 1949-1951, 2004.

Ivanov AI, Patel S, Kulchitsky VA, Romanovsky AA. Platelet-activating factor: a previously unrecognized mediator of fever. J Physiol 553: 221-228, 2003.

Free PDFs of the publications listed above can be downloaded or requested from the Publications page.